The Laboratory of Epilepsy and Neurodevelopment

• Manent JB, Wang Y, Chang Y, Paramasivam M, LoTurco JJ: Dcx reexpression reduces subcortical band heterotopia and seizure threshold in an animal model of neuronal migration disorder. Nat Med 15(1):84-90, 2009. PM19098909/PMC2715867

• Wang Y, Yin X, Rosen G, Gabel L, Guadiana SM, Sarkisian MR, Galaburda AM, Loturco JJ: Dcdc2 knockout mice display exacerbated developmental disruptions following knockdown of doublecortin. Neuroscience 190: 398-408, 2011. PM21689730/PMC3170724

• Wang Y, Ji T, Nelson AD, Glanowska K, Murphy GG, Jenkins PM, Parent JM: Critical roles of αII spectrin in brain development and epileptic encephalopathy. J Clin Invest 128(2): 760-773, 2018. PM29337302/PMC5785268

• Hu S, Knowlton RC, Watson BO, Glanowska KM, Murphy GG, Parent JM, Wang Y: Somatic Depdc5 deletion recapitulates electroclinical features of human focal cortical dysplasia type IIA. Ann Neurol 84(1): 140-146, 2018. PM30080265/PMC6119494

•  Hu S, Yang T, Wang Y: Widespread labeling and genomic editing of the fetal central nervous system by in utero CRISPR AAV9-PHP.eB administration. Development 148(2): 2021. PM33334860/PMC7847274

• Kao HY, Hu S, Mihaylova T, Ziobro J, Ahn E, Fine C, Brang D, Watson BO, Wang Y: Defining the latent period of epileptogenesis and epileptogenic zone in a focal cortical dysplasia type II (FCDII) rat model. Epilepsia 62(5): 1268-1279, 2021. PM33735460/PMC8211029

• Hu S, Kao HY, Yang T, Wang Y: Early and Bi-hemispheric seizure onset in a rat glioblastoma Multiforme model. Neurosci Lett 766: 2022. PM34793898/PMC8642883

• Yang T, Hu ST, Chang WC, Kao HY, Wang Y: Perineuronal nets degradation and parvalbumin interneuron loss in a mouse model of DEPDC5-related epilepsy. Dev Neurosci, 44(6): 2022. PM35580549

• Kao HY,  Yao YL, Yang T, Ziobro J, Zylinski M,  Mir MY, Hu ST, Cao RN, Borna NN, Banerjee R, Parent JM, Wang S, Leventhal DK, Li P, Wang Y. Sudden unexpected death in epilepsy and respiratory defects in a mouse model of DEPDC5-related Epilepsy. Ann  Neurol, 2023. PM37606181.

U54NS117170 (Isom and Parent) NINDS 09/2020-07/2025

Epilepsy Multiplatform Variant Prediction (EpiMVP)

 Project 3 (Wang and Baraban): Cell Systems to Pre-Clinical Models 

R01 NS113824 (Wang)  NINDS 9/2019~5/2024

Cortical development and pathogenesis in DEPDC5-related epilepsies